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Ciclopirox

Cat. No. 6384 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Pan-histone demethylase inhibitor
化学名： 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
纯度： ≥99% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ciclopirox

Ciclopirox is a pan-histone demethylase inhibitor. Exhibits no significant effect on histone deacetylases. Inhibits MYC-signaling and proliferation of neuroblastoma cells. Promotes Cdc25A-degradation in cancer cells. Antifungal.

化合物库 for Ciclopirox

Ciclopirox is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Ciclopirox

分子量 207.27
公式 C12H17NO2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 29342-05-0
PubChem ID 2749
InChI Key SCKYRAXSEDYPSA-UHFFFAOYSA-N
Smiles CC1=CC(N(C(C2CCCCC2)=C1)O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ciclopirox

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.73 100
ethanol 20.73 100

制备储备液 for Ciclopirox

以下数据基于产品分子量 207.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.82 mL 24.12 mL 48.25 mL
5 mM 0.96 mL 4.82 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.82 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

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参考文献 for Ciclopirox

参考文献是支持产品生物活性的出版物。

Shen et al (2017) Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A. Genes Cancer 8 505 PMID: 28680535

Yang et al (2017) Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox. Cancer Res. 77 4626 PMID: 28684529

If you know of a relevant reference for Ciclopirox, please let us know.

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关键词: Ciclopirox, Ciclopirox supplier, pan, histone, demethylase, inhibitors, inhibits, antifungal, anticancer, KDM, Histone, Demethylases, Antifungals, 6384, Tocris Bioscience

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该领域的文献

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Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.