Cilastatin sodium

Name: Cilastatin sodium
Brand: Tocris Bioscience
SKU: 2709

Cat. No. 2709 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2709 has been discontinued.

View all Other Proteases products.

说明： Dipeptidase inhibitor

别名： MK 0791

化学名： (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid sodium salt

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Cilastatin sodium

Cilastatin sodium is a dipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a K_i value of 0.11 μM. Inhibits metabolism of LTD₄ to LTE₄ and the hydrolysis of β-lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.

技术数据 for Cilastatin sodium

分子量	380.43
公式	C₁₆H₂₅N₂NaO₅S
储存	Desiccate at -20°C
纯度	≥99% (HPLC)
CAS Number	81129-83-1
PubChem ID	23702512
InChI Key	QXPBTTUOVWMPJN-VQAYNFQASA-M
Smiles	[Na+].N[C@H](CSCCCC\C=C(/NC(=O)[C@H]1CC1(C)C)C(O)=O)C([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Cilastatin sodium

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cilastatin sodium

参考文献是支持产品生物活性的出版物。

Graham et al (1987) Inhibition of the mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids. J.Med.Chem. 30 1074 PMID: 3495664

White et al (1999) A continuous fluorometric assay for leukotriene D₄ hydrolase. Anal.Biochem. 268 245 PMID: 10075814

Perez et al (2004) Inhibition of brush border dipeptidase with cilas. reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. Nephrol.Dial.Transplant. 19 2445 PMID: 15252165

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关键词: Cilastatin sodium, Cilastatin sodium supplier, Dipeptidase, LTDase, leukotrienes, eicosanoids, D4, hydrolase, dehydropeptidase, I, inhibitors, inhibits, metabolism, LTD4, LTE4, Proteases, Proteinases, MK0791, MK, 0791, Other, Leukotriene, and, Related, Receptors, 2709, Tocris Bioscience

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