CL 82198 hydrochloride

Cat. No. 2632 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective inhibitor of MMP-13

化学名： N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride

纯度： ≥98% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CL 82198 hydrochloride

CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.

化合物库 for CL 82198 hydrochloride

CL 82198 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CL 82198 hydrochloride

分子量	338.83
公式	C₁₇H₂₃N₂O₃.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1188890-36-9
PubChem ID	16760373
InChI Key	PIOACXKZWXHBRB-UHFFFAOYSA-N
Smiles	Cl.O=C(NCCCCN1CCOCC1)C1=CC2=CC=CC=C2O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CL 82198 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	33.88	100
	DMSO	25.41	75

制备储备液 for CL 82198 hydrochloride

以下数据基于产品分子量 338.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.76 mL	29.51 mL
5 mM	0.59 mL	2.95 mL	5.9 mL
10 mM	0.3 mL	1.48 mL	2.95 mL
50 mM	0.06 mL	0.3 mL	0.59 mL

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产品说明书 for CL 82198 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CL 82198 hydrochloride

参考文献是支持产品生物活性的出版物。

Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648

Borg et al (2003) IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr. 5 122

Lisse et al (2016) PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A 113 E2189 PMID: 27035978

If you know of a relevant reference for CL 82198 hydrochloride, please let us know.

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3 篇 CL 82198 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CL 82198 hydrochloride 的部分引用包括：

Meierjohann et al (2010) MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer 9 201 PMID: 20667128

Lisse et al (2016) PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A 113 E2189 PMID: 27035978

Wang et al (2013) MMP13 is a critical target gene during the progression of osteoarthritis. J Neurosci 15 R5 PMID: 23298463

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