Colivelin

Cat. No. 3945 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： STAT3 activator; also protects against β-amyloid neurotoxicity

纯度： ≥95% (HPLC)

引用文献 (3)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Colivelin

Colivelin is a neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.

技术数据 for Colivelin

分子量	2645.13
公式	C₁₁₉H₂₀₆N₃₂O₃₅
序列	SALLRSIPAPAGASRLLLLTGEIDLP
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	867021-83-8
PubChem ID	90477169
InChI Key	PTTAQOYOJJTWFD-IBAOLXMASA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Colivelin

溶解性	Soluble to 1 mg/ml in 20% ethanol / water

产品说明书 for Colivelin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Colivelin

参考文献是支持产品生物活性的出版物。

Chiba et al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro a J.Neurosci. 25 10252 PMID: 16267233

Sari et al (2009) A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 164 1653 PMID: 19782727

Yamada et al (2008) Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 33 2020 PMID: 17928813

If you know of a relevant reference for Colivelin, please let us know.

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关键词: Colivelin, Colivelin supplier, neuroprotectant, neuroprotective, beta-amyloid, b-amyloid, β-amyloid, alzheimers, disease, STAT3, amyloidbeta, amyloidb, amyloidβ, Amyloid, Beta, Peptides, STAT, 3945, Tocris Bioscience

3 篇 Colivelin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Colivelin 的部分引用包括：

Vergani et al (2013) Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. J Cell Biol 127 463 PMID: 23250993

Li et al (2017) The ameliorative effect of fluoxetine on neuroinflammation induced by sleep deprivation. J Neurochem PMID: 29222907

Xiaodong et al (2019) TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti-PD-1 Therapy in Melanoma. Cancer Immunol Res 7 1672-1686 PMID: 31451482

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Pathways for Colivelin

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.