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Submit ReviewConcanamycin A
说明： H+-ATPase (vacuolar) inhibitor
别名： Folimycin
化学名： (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one
纯度： ≥90% (HPLC)
生物活性 for Concanamycin A
Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.
技术数据 for Concanamycin A
| 分子量 | 866.09 |
| 公式 | C46H75NO14 |
| 储存 | Store at -20°C |
| 纯度 | ≥90% (HPLC) |
| CAS Number | 80890-47-7 |
| PubChem ID | 6438151 |
| InChI Key | DJZCTUVALDDONK-HQMSUKCRSA-N |
| Smiles | O=C1O[C@@]([C@@H](C)[C@@H](O)[C@H](C)[C@]2(O)O[C@H](/C=C/C)[C@@H](C)[C@H](O[C@]3([H])O[C@H](C)[C@@H](OC(N)=O)[C@H](O)C3)C2)([H])[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C=C1\OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Concanamycin A
| 溶解性 | Soluble in DMSO |
产品说明书 for Concanamycin A
参考文献 for Concanamycin A
参考文献是支持产品生物活性的出版物。
Hong et al (2006) Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. J.Pharmacol.Exp.Ther. 319 672 PMID: 16895977
Muroi et al (1993) Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus. Cell Struct.Function. 18 139
Nishihara et al (1995) Specific inhibitors of vacuolar type H+-ATPases induce apoptotic cell death. Biochem.Biophy.Res.Comm. 212 255
If you know of a relevant reference for Concanamycin A, please let us know.
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关键词: Concanamycin A, Concanamycin A supplier, H+-ATPase, vacuolar, inhibitors, inhibits, V-Type, Hydrogen-ATPases, Ion, Transporters, Pumps, ConcanamycinA, antibiotics, Folimycin, Antibiotics, Autophagy, 2656, Tocris Bioscience
2 篇 Concanamycin A 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Concanamycin A 的部分引用包括：
Gomes-da-Silva et al (2019) Recruitment of LC3 to damaged Golgi apparatus. Cell Death Differ 26 1467 PMID: 30349077
Chabaud et al (2015) Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nat Commun 6 7526 PMID: 26109323
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