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Cordycepin

Cat. No. 2294 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： RNA synthesis inhibitor
化学名： 3'-Deoxyadenosine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Cordycepin

Cordycepin is a nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.

技术数据 for Cordycepin

分子量 251.24
公式 C10H13N5O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 73-03-0
PubChem ID 6303
InChI Key OFEZSBMBBKLLBJ-BAJZRUMYSA-N
Smiles NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CO)C[C@H]3O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cordycepin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.12 100

制备储备液 for Cordycepin

以下数据基于产品分子量 251.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.98 mL 19.9 mL 39.8 mL
5 mM 0.8 mL 3.98 mL 7.96 mL
10 mM 0.4 mL 1.99 mL 3.98 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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产品说明书 for Cordycepin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Cordycepin

参考文献是支持产品生物活性的出版物。

Gumport and Edelhei et al (1976) The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli. Biochemistry 15 2804 PMID: 779831

Sugar and McCaffrey (1998) Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob.Agents Chemother. 42 1424 PMID: 9624488

Kodama et al (2000) Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem.Pharmacol. 59 273 PMID: 10609556

If you know of a relevant reference for Cordycepin, please let us know.

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关键词: Cordycepin, Cordycepin supplier, RNA, synthesis, inhibitors, inhibits, Protein, DNA, DNA,, and, Synthesis, 2294, Tocris Bioscience

1 篇 Cordycepin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cordycepin 的部分引用包括：

Petropoulos et al (2024) Transcription-replication conflicts underlie sensitivity to PARP inhibitors. Nature 628 433 PMID: 38509368

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Cordycepin 的评论

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Cordycepin inhibits growth of melanoma cell line at micromolar concentrations.
By Anonymous on 02/07/2019
分析类型： In Vitro
种属： Human
细胞系/组织： SK-MEL-28

Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).

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