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Covidcil-19

Cat. No. 7485 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Binds to SARS-CoV-2 frameshifting element and reduces frameshifting efficiency
化学名： 3-[[4-(Methylamino)-2-quinazolinyl]amino]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Covidcil-19

Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.

技术数据 for Covidcil-19

分子量 294.31
公式 C16H14N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1225177-95-6
PubChem ID 52108194
InChI Key ATKIOCNKZKNVQS-UHFFFAOYSA-N
Smiles CNC1=NC(NC2=CC(C(O)=O)=CC=C2)=NC3=C1C=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Covidcil-19

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.94 10

制备储备液 for Covidcil-19

以下数据基于产品分子量 294.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 33.98 mL 169.89 mL 339.78 mL
0.5 mM 6.8 mL 33.98 mL 67.96 mL
1 mM 3.4 mL 16.99 mL 33.98 mL
5 mM 0.68 mL 3.4 mL 6.8 mL

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Reconstitution Calculator

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参考文献 for Covidcil-19

参考文献是支持产品生物活性的出版物。

Haniff et al (2020) Targeting the SARS-CoV-2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders. ACS Cent.Sci. 6 1713 PMID: 33140033

Giorgio et al (2020) New chemical modalities enabling specific RNA targeting and degradation: application to SARS-CoV-2 RNA. ACS Cent.Sci. 6 1647 PMID: 33140031

If you know of a relevant reference for Covidcil-19, please let us know.

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关键词: Covidcil-19, Covidcil-19 supplier, high, affinity, revised, attenuator, hairpin, structure, SARS-CoV-2, frameshifting, element, FSE, reduces, efficiency, COVID-19, DNA,, RNA, and, Protein, Synthesis, Coronavirus, 7485, Tocris Bioscience

篇 Covidcil-19 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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