CP 376395 hydrochloride

Cat. No. 3212 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective CRF₁ antagonist; binds at an allosteric site

化学名： N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride

纯度： ≥99% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CP 376395 hydrochloride

CP 376395 hydrochloride is a potent and selective CRF₁ receptor antagonist (K_i values are 12 and >10000 nM for CRF₁ and CRF₂ receptors respectively). Binds at an allosteric site. Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active.

化合物库 for CP 376395 hydrochloride

CP 376395 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CP 376395 hydrochloride

分子量	362.94
公式	C₂₁H₃₀N₂O.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	1013933-37-3
PubChem ID	24806455
InChI Key	UDIOZDHQQNYISB-UHFFFAOYSA-N
Smiles	CC1=CC(NC(CC)CC)=C(C)C(OC2=C(C)C=C(C)C=C2C)=N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CP 376395 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	18.15	50
	DMSO	36.29	100

制备储备液 for CP 376395 hydrochloride

以下数据基于产品分子量 362.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.78 mL	27.55 mL
5 mM	0.55 mL	2.76 mL	5.51 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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产品说明书 for CP 376395 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CP 376395 hydrochloride

参考文献是支持产品生物活性的出版物。

Chen et al (2008) 2-Aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J.Med.Chem. 51 1385 PMID: 18288792

Hollenstein et al (2013) Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature 499 438 PMID: 23863939

Lu et al (2019) Small molecule allosteric modulators of G-protein-coupled receptors: drug-target interactions. J.Med.Chem. 62 24 PMID: 29457894

If you know of a relevant reference for CP 376395 hydrochloride, please let us know.

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3 篇 CP 376395 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CP 376395 hydrochloride 的部分引用包括：

Tran et al (2014) Importance of CRF receptor-mediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain. Neuropsychopharmacology 39 2633 PMID: 24853772

Kean et al (2015) Conformational thermostabilisation of cortico. releasing factor receptor 1. Mol Pain 5 11954 PMID: 26159865

Boyson et al (2014) Social stress and CRF-DA interactions in the VTA: role in long-term escalation of cocaine self-administration. J Neurosci 34 6659 PMID: 24806691

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