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Submit ReviewCP 424174
说明： Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
化学名： N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
纯度： ≥98% (HPLC)
生物活性 for CP 424174
CP 424174 is an inhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for CP 424174
| 分子量 | 452.99 |
| 公式 | C22H29ClN2O4S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 210825-31-3 |
| PubChem ID | 9911728 |
| InChI Key | YRSBLSHMKVQWHP-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC(C(O)(C)C)=CC=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CP 424174
参考文献 for CP 424174
参考文献是支持产品生物活性的出版物。
Perregaux et al (2001) Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 299 187 PMID: 11561079
Baldwin et al (2016) Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 59 1691 PMID: 26422006
关键词: CP 424174, CP 424174 supplier, CP424174, Inhibitor, IL-1, beta, post-translational, processing, β, NLRP3, inflammasomes, in, vivo, orally, bioavailable, Cytokines, Inflammasomes, 6107, Tocris Bioscience
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