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CP 96345

Cat. No. 2893 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective NK1 antagonist
化学名： (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CP 96345

CP 96345 is a potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for CP 96345

CP 96345 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CP 96345

分子量 412.57
公式 C28H32N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 132746-60-2
PubChem ID 104943
InChI Key FLNYLINBEZROPL-NSOVKSMOSA-N
Smiles COC(C=CC=C3)=C3CN[C@H]1C(CC4)CCN4[C@H]1[C@H](C5=CC=CC=C5)C2=CC=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CP 96345

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 8.25 20 温和加热

制备储备液 for CP 96345

以下数据基于产品分子量 412.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 12.12 mL 60.6 mL 121.19 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
2 mM 1.21 mL 6.06 mL 12.12 mL
10 mM 0.24 mL 1.21 mL 2.42 mL

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参考文献 for CP 96345

参考文献是支持产品生物活性的出版物。

Snider et al (1991) A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 251 435 PMID: 1703323

Lembeck et al (1992) The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol. 105 527 PMID: 1378337

Bang et al (2003) Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther. 305 31 PMID: 12649350

If you know of a relevant reference for CP 96345, please let us know.

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关键词: CP 96345, CP 96345 supplier, Potent, selective, nonpeptide, NK1, receptors, antagonists, tachykinin, neurokinin, CP96345, Pfizer, Receptor, 2893, Tocris Bioscience

1 篇 CP 96345 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CP 96345 的部分引用包括：

Silva et al (2015) Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice. Br J Pharmacol 172 924 PMID: 25298144

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