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Submit ReviewCP 99994 dihydrochloride
说明： High affinity NK1 antagonist
化学名： (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride
纯度： ≥99% (HPLC)
生物活性 for CP 99994 dihydrochloride
CP 99994 dihydrochloride is a high affinity NK1 antagonist (Ki = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for CP 99994 dihydrochloride
CP 99994 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CP 99994 dihydrochloride
| 分子量 | 369.33 |
| 公式 | C19H24N2O.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 145148-39-6 |
| PubChem ID | 68466923 |
| InChI Key | WNHRFWPLRATIDT-FFUVTKDNSA-N |
| Smiles | COC(C=CC=C3)=C3CN[C@@H]1[C@H]([C@]2=CC=CC=C2)NCCC1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CP 99994 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 36.93 | 100 | |
| DMSO | 18.47 | 50 |
制备储备液 for CP 99994 dihydrochloride
以下数据基于产品分子量 369.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.71 mL | 13.54 mL | 27.08 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.42 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.71 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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产品说明书 for CP 99994 dihydrochloride
参考文献 for CP 99994 dihydrochloride
参考文献是支持产品生物活性的出版物。
Shirahase et al (1995) Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2. Br.J.Pharmacol. 115 1215 PMID: 7582548
Duffy et al (2002) Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther. 301 536 PMID: 11961054
Lindstrom et al (2007) Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy. J.Pharmacol.Exp.Ther. 322 1286 PMID: 17575073
If you know of a relevant reference for CP 99994 dihydrochloride, please let us know.
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关键词: CP 99994 dihydrochloride, CP 99994 dihydrochloride supplier, pfizer, CP99994, neurokinin, 1, receptors, nk1, tachykinin, substance, p, antagonists, NK1, Receptor, 3417, Tocris Bioscience
7 篇 CP 99994 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CP 99994 dihydrochloride 的部分引用包括：
Horn et al (2013) Novel dynamic measures of emetic behavior in musk shrews. Nature 179 60 PMID: 23953843
Wei et al (2015) Differential Gene Expression Profile in the Rat Caudal Vestibular Nucleus is Associated with Individual Differences in Motion Sickness Susceptibility. PLoS One 10 e0124203 PMID: 25910039
Craig L et al (2021) Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease. Am J Physiol Heart Circ Physiol 320 H1887-H1902 PMID: 33710922
Christina T et al (2020) nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice. Elife 9 PMID: 33016877
Suyun et al (2020) N-benzhydryl quinuclidine compounds are a potent and Src kinase-independent inhibitor of NALCN channels. Br J Pharmacol 177 3795-3810 PMID: 32436268
Yin et al (2018) Crystal structure of the human NK1 tachykinin receptor. Proc.Natl.Acad.Sci.U.S.A. 115 13264 PMID: 30538204
Sheahan et al (2020) The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J.Neurosci 40 8816 PMID: 33051347
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