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Submit ReviewCPI 203
说明： BET bromodomain inhibitor; arrests cell cycle at G1 phase
别名： TEN 010
化学名： (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
纯度： ≥98% (HPLC)
生物活性 for CPI 203
CPI 203 is a BET bromodomain inhibitor. Downregulates Myc expression, causes G1 cell cycle arrest and attenuates cell proliferation in human pancreatic neuroendocrine tumors. Arrests the growth of T cell acute lymphoblastic leukemia cells in vitro (EC50 = 91.2 nM). Also enhances the antitumor effect of rapamycin (Cat. No. 1292) in vitro and attenuates rapamycin induced Akt activation. Also enhances fibroblast reprogramming to hiPSCs at low concentration. Orally bioavailable.
化合物库 for CPI 203
CPI 203 is also offered as part of the Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for CPI 203
| 分子量 | 399.9 |
| 公式 | C19H18ClN5OS |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1446144-04-2 |
| PubChem ID | 71291068 |
| InChI Key | QECMENZMDBOLDR-AWEZNQCLSA-N |
| Smiles | NC(C[C@@H]1N=C(C4=CC=C(Cl)C=C4)C3=C(SC(C)=C3C)N2C1=NN=C2C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CPI 203
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 39.99 | 100 | |
| ethanol | 4 | 10 |
制备储备液 for CPI 203
以下数据基于产品分子量 399.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.5 mL | 12.5 mL | 25.01 mL |
| 5 mM | 0.5 mL | 2.5 mL | 5 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.5 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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产品说明书 for CPI 203
参考文献 for CPI 203
参考文献是支持产品生物活性的出版物。
Wong et al (2014) The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors. Cell Death Dis. 5 e1450 PMID: 25299775
King et al (2013) The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 153 1552 PMID: 23791182
Shao et al (2016) Reprogramming by de-bookmarking the somatic transcriptional program through targeting of BET bromodomains. Cell Rep. 16 3138 PMID: 27653680
If you know of a relevant reference for CPI 203, please let us know.
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关键词: CPI 203, CPI 203 supplier, CPI203, BET, BRD4, domain, inhibitors, inhibits, (+)-JQ1, analogue, analog, 4499, Myc, G1, cell, cycle, arrest, antitumor, rapamycin, AKT, reprogramming, TEN, 010, Bromodomains, Cell, Cycle, Inhibitors, Stem, Reprogramming, Hematopoietic, Cells, 5331, Tocris Bioscience
1 篇 CPI 203 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CPI 203 的部分引用包括：
Shao et al (2016) Reprogramming by de-bookmarking the somatic transcriptional program through targeting of BET bromodomains. Cell Rep. 16 3138 PMID: 27653680
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CPI 203 的评论
平均评分: 5 (Based on 1 Review.)
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Reprogramming media with CPI203.
By
Anonymous on 02/23/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： ipsc
50 nM
该领域的文献
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