Cryptotanshinone

Name: Cryptotanshinone
Brand: Tocris Bioscience
SKU: 3713

Cat. No. 3713 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3713 has been discontinued.

View all STATs products.

说明： STAT3 inhibitor. Also displays multiple other activities

化学名： 1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b]furan-10,11-dione

纯度： ≥98% (HPLC)

说明书

引用文献

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for Cryptotanshinone

Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC₅₀ = 4.6 μM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC₅₀ = 4.09 μM) and reduction in Aβ peptide generation.

技术数据 for Cryptotanshinone

分子量	296.36
公式	C₁₉H₂₀O₃
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	35825-57-1
PubChem ID	160254
InChI Key	GVKKJJOMQCNPGB-JTQLQIEISA-N
Smiles	O=C(C1=C(C4=C3[C@@H](C)CO4)C=CC2=C1CCCC(C)2C)C3=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Cryptotanshinone

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cryptotanshinone

参考文献是支持产品生物活性的出版物。

Kim et al (2007) Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Mol.Pharmacol. 72 62 PMID: 17429005

Shin et al (2009) Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 69 193 PMID: 19118003

Zhang et al (2009) Cryptotanshinone, a compound from Saliva miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro. Neurosci.Letts. 452 90

Wong et al (2009) Cryptotanshinone, an acetylcholinesterase inhibitor from Salivia miltiorrhiza, ameliorates scopolamine-induced amnesia in morris water maze task. Planta Med. 76 288

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关键词: Cryptotanshinone, Cryptotanshinone supplier, acetylcholinesterases, inhibitors, inhibits, Abeta, amyloid-beta, beta-amyloid, b-amyloid, AMP-activated, protein, kinases, AMPK, STAT3, signal, transducers, activators, transcription, factors, β-amyloid, amyloidb, amyloidβ, STAT, Amyloid, Beta, Peptides, Cholinesterases, 3713, Tocris Bioscience

篇 Cryptotanshinone 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Cryptotanshinone 的引用文献。