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CYM 50260

Cat. No. 4677 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective S1P4 agonist
化学名： 2-Chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CYM 50260

CYM 50260 is a potent sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 = 45 nM). Displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM.

化合物库 for CYM 50260

CYM 50260 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CYM 50260

分子量 350.6
公式 C14H11Cl3FNO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1355026-60-6
PubChem ID 44620894
InChI Key FHPOTBQOUBMMCI-UHFFFAOYSA-N
Smiles ClC1=CC(Cl)=C(OCCOC2=CC=C(CF)N=C2Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CYM 50260

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.06 100

制备储备液 for CYM 50260

以下数据基于产品分子量 350.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.26 mL 28.52 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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参考文献 for CYM 50260

参考文献是支持产品生物活性的出版物。

Guerrero et al (2011) Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists. Bioorg.Med.Chem.Lett. 22 537 PMID: 22119461

If you know of a relevant reference for CYM 50260, please let us know.

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关键词: CYM 50260, CYM 50260 supplier, CYM50260, sphingosine-1-phosphate, receptors, S1P4, agonists, potent, selective, Sphingosine-1-phosphate, Receptors, 4677, Tocris Bioscience

1 篇 CYM 50260 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CYM 50260 的部分引用包括：

Matsushima-Nishiwaki R et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2 PLoS One 13 e0209050 PMID: 30543684

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