CYM 5442 hydrochloride

Cat. No. 3601 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective S1P₁ receptor agonist

化学名： 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride

纯度： ≥98% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CYM 5442 hydrochloride

CYM 5442 hydrochloride is a potent and selective S1P₁ agonist in vitro (EC₅₀ = 1.35 nM). Activates S1P₁-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P₁. Induces acute lymphopenia in mice. Brain penetrant.

化合物库 for CYM 5442 hydrochloride

CYM 5442 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CYM 5442 hydrochloride

分子量	445.94
公式	C₂₃H₂₇N₃O₄.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1783987-80-3
PubChem ID	90488865
InChI Key	KMZLVDAVGXYZDA-UHFFFAOYSA-N
Smiles	OCCNC3CCC(C3=CC=C4)=C4C1=NOC(C2=CC(OCC)=C(OCC)C=C2)=N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CYM 5442 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	44.59	100

制备储备液 for CYM 5442 hydrochloride

以下数据基于产品分子量 445.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.21 mL	22.42 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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产品说明书 for CYM 5442 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CYM 5442 hydrochloride

参考文献是支持产品生物活性的出版物。

Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Mol.Pharmacol. 74 1308 PMID: 18708635

If you know of a relevant reference for CYM 5442 hydrochloride, please let us know.

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Sphingosine-1-Phosphate Receptors

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