CYM 5541

Cat. No. 4897 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective S1P₃ receptor allosteric agonist

化学名： N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

纯度： ≥97% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CYM 5541

CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P₃) allosteric agonist (EC₅₀ = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P₃ than S1P. Displays no activity at S1P₁, S1P₂, S1P₄ and S1P₅ receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

化合物库 for CYM 5541

CYM 5541 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CYM 5541

分子量	316.44
公式	C₁₉H₂₈N₂O₂
储存	Store at +4°C
纯度	≥97% (HPLC)
CAS Number	945128-26-7
PubChem ID	17253208
InChI Key	NDKGACIWVAOUQH-UHFFFAOYSA-N
Smiles	O=C(N(C3CCCCC3)C2CCCCC2)C1=NOC(C4CC4)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CYM 5541

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	31.64	100
	ethanol	15.82	50

制备储备液 for CYM 5541

以下数据基于产品分子量 316.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.16 mL	15.8 mL	31.6 mL
5 mM	0.63 mL	3.16 mL	6.32 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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产品说明书 for CYM 5541

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CYM 5541

参考文献是支持产品生物活性的出版物。

Jo et al (2012) Novel selective allosteric and bitopic ligands for the S1P₃ receptor. ACS Chem.Biol. 7 1975 PMID: 22971058

If you know of a relevant reference for CYM 5541, please let us know.

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Sphingosine-1-Phosphate Receptors

关键词: CYM 5541, CYM 5541 supplier, CYM5541, Selective, S1P3, receptors, allosteric, agonists, SIP, Sphingosine-1-phosphate, Sphingosine, Receptors, 4897, Tocris Bioscience