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Cytarabine

Cat. No. 4520 6 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Nucleoside analog; inhibits DNA replication
别名： Cytosine b-D-arabinofuranoside
化学名： 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
纯度： ≥98% (HPLC)
说明书
引用文献 (6)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Cytarabine

Cytarabine is a nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.

技术数据 for Cytarabine

分子量 243.22
公式 C9H13N3O5
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 147-94-4
PubChem ID 114682
InChI Key UHDGCWIWMRVCDJ-STUHELBRSA-N
Smiles O[C@@H]1[C@@H](CO)OC(N2C=CC(N)=NC2=O)[C@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cytarabine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 24.32 100
DMSO 12.16 50

制备储备液 for Cytarabine

以下数据基于产品分子量 243.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.11 mL 20.56 mL 41.12 mL
5 mM 0.82 mL 4.11 mL 8.22 mL
10 mM 0.41 mL 2.06 mL 4.11 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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产品说明书 for Cytarabine

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Cytarabine

参考文献是支持产品生物活性的出版物。

Sampath et al (2006) Pharmacodynamics of cytar. alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. 107 2517 PMID: 16293603

Breistøl et al (1999) Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytar. in metastatic and s.c. human tumor xenograft models. Cancer Res. 59 2944 PMID: 10383159

Yang et al (1986) Effect of cytar. upon metabolism of phospholipids in leukemia L5178Y cells. Acta Pharmacol. Sin. 7 368 PMID: 2954403

If you know of a relevant reference for Cytarabine, please let us know.

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关键词: Cytarabine, Cytarabine supplier, Cytarabine, supplier, ara-C, araC, cytosine, beta-D-arabinofuranoside, arabinocytidine, DNA, replication, inhibits, nucleoside, analog, deoxycytidine, incorporates, synthesis, anticancer, antiproliferative, antineoplastic, antileukemic, leukemia, fragmentation, antimetabolite, Cytosine, b-D-arabinofuranoside, DNA,, RNA, and, Protein, Synthesis, 4520, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Cytarabine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

6 篇 Cytarabine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cytarabine 的部分引用包括：

Mathieson et al (2018) Systematic analysis of protein turnover in primary cells. Nat Commun 9 689 PMID: 29449567

Uwe et al (2021) The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG. Cancer Discov 11 500-519 PMID: 33028621

Karen et al (2021) Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors. Curr Protoc 1 e141 PMID: 34102035

Paul A et al (2019) Knockdown of BNIP3L or SQSTM1 alters cellular response to mitochondria target drugs. Autophagy 15 900-907 PMID: 30563411

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Cytarabine 的评论

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An inhibitor of neurogenesis.
By Luiz Alexandre Magno on 07/16/2018
分析类型： In Vivo
种属： Mouse
细胞系/组织： Brain

Cytarabine, also known as AraC, is an anti-mitotic drug. I have used it to inhibit neurogenesis. To deliver this drug into the brain, I implanted a chronic osmotic minipump with cannula located in the lateral ventricle of mice. The drug was diluted in NaCl 0.9% at 2% concentration (m/v) and delivered for 14 days. After treatment, a proliferative zone of the brain was immunolabeled for the doublecortin marker, which stains new neurons. The image shows that the mouse injected with Cytarabine (RIGHT) displayed no signal of new cells, suggesting that neurogenesis was blocked.

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