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Submit ReviewD-Amphetamine sulfate
说明： Induces dopamine, 5-HT and noradrenalin release; also α7 nAChR antagonist
别名： Dextroamphetamine sulfate
化学名： (+)-α-Methylphenethylamine hemisulfate salt
纯度： ≥99% (HPLC)
生物活性 for D-Amphetamine sulfate
D-Amphetamine sulfate is a cNS stimulant. Targets monoamine transporters to elevate synaptic levels of noradrenalin, dopamine and serotonin. Also α7 nAChR antagonist.
技术数据 for D-Amphetamine sulfate
| 分子量 | 184.25 |
| 公式 | C9H13N.1/2H2SO4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 51-63-8 |
| PubChem ID | 5825 |
| InChI Key | PYHRZPFZZDCOPH-QXGOIDDHSA-N |
| Smiles | N[C@@H](C)CC1=CC=CC=C1.N[C@@H](C)CC2=CC=CC=C2.OS(O)(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for D-Amphetamine sulfate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 18.43 | 100 |
制备储备液 for D-Amphetamine sulfate
以下数据基于产品分子量 184.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.43 mL | 27.14 mL | 54.27 mL |
| 5 mM | 1.09 mL | 5.43 mL | 10.85 mL |
| 10 mM | 0.54 mL | 2.71 mL | 5.43 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.09 mL |
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产品说明书 for D-Amphetamine sulfate
参考文献 for D-Amphetamine sulfate
参考文献是支持产品生物活性的出版物。
Barr et al (1999) Effects of withdrawal from an escalating dose schedule of d-Amphetamine on sexual behavior in the male rat. Pharmacol.Biochem.Behav. 64 597 PMID: 10548277
Cartmell et al (1999) The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-Amphetamine motor behaviors in rats. J.Pharmacol.Exp.Ther. 291 161 PMID: 10490900
Rothman and Baumann (2006) Balance between DA and serotonin release modulates behavioral effects of Amphetamine-type drugs. Ann.N.Y.Acad.Sci. 1074 245 PMID: 17105921
Garton et al (2018) Amphetamine enantiomers inhibit homomeric a7 nicotinic receptor through a competitive mechanism and within the intoxication levels in humans. Neuropharmacology PMID: 30359640
If you know of a relevant reference for D-Amphetamine sulfate, please let us know.
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关键词: D-Amphetamine sulfate, D-Amphetamine sulfate supplier, Induces, 5-HT, dopamine, noradrenaline, release, Serotonin, 5-Hydroxytryptamine, amphetamine, Dextroamphetamine, sulfate, Dopaminergic-Related, Adrenergic, Related, Compounds, 5-HT-Related, 5-HT3, Receptors, Nicotinic, (a7), 2813, Tocris Bioscience
8 篇 D-Amphetamine sulfate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 D-Amphetamine sulfate 的部分引用包括：
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
Beerepoot et al (2016) Pharmacological Chaperones of the DA Transporter Rescue DA Transporter Deficiency Syndrome Mutations in Heterologous Cells. J Biol Chem 291 22053 PMID: 27555326
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. PLoS One 40 766 PMID: 25249058
Sánchez-Blázquez et al (2018) Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice. Int J Neuropsychopharmacol 21 938 PMID: 29860313
Palmér et al (2017) Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development. Sci Rep 7 3191 PMID: 28600565
Garton et al (2019) Amphetamine enantiomers inhibit homomeric α7 nicotinic receptor through a competitive mechanism and within the intoxication levels in humans. Neuropharmacology 144 172 PMID: 30359640
Ribeiro et al (2014) Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease. Neuropsychopharmacology 23 2030 PMID: 24282028
Soda et al (2013) DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Mol Psychiatry 18 898 PMID: 23587879
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.