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Darunavir

Cat. No. 6710 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent HIV protease inhibitor
化学名： (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Darunavir

Darunavir is a highly potent HIV protease inhibitor (IC50 = 3 - 6 nM, depending on laboratory HIV-1 strain). Displays activity in cells infected with clinical HIV-1 strains shown to have resistance to other protease inhibitors.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

化合物库 for Darunavir

Darunavir is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Darunavir

分子量 547.66
公式 C27H37N3O7S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 206361-99-1
PubChem ID 213039
InChI Key CJBJHOAVZSMMDJ-HEXNFIEUSA-N
Smiles [H][C@@]12CCO[C@@]1(OC[C@@H]2OC(N[C@H]([C@@H](CN(S(=O)(C3=CC=C(C=C3)N)=O)CC(C)C)O)CC4=CC=CC=C4)=O)[H]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Darunavir

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 54.77 100

制备储备液 for Darunavir

以下数据基于产品分子量 547.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.13 mL 18.26 mL
5 mM 0.37 mL 1.83 mL 3.65 mL
10 mM 0.18 mL 0.91 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Molarity Calculator

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参考文献 for Darunavir

参考文献是支持产品生物活性的出版物。

Ghosh et al (1998) Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere. Bioorg.Med.Chem.Lett. 8 687 PMID: 9871583

Koh et al (2003) Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob.Agents Chemother. 47 3123 PMID: 14506019

If you know of a relevant reference for Darunavir, please let us know.

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关键词: Darunavir, Darunavir supplier, HIV, human, immunodeficiency, virus, protease, inhibitor, highly, potent, TMC114, TMC, 114, antiviral, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Plpro, papain-like, Protease, 6710, Tocris Bioscience

篇 Darunavir 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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Darunavir 的评论

平均评分: 5 (Based on 1 Review.)

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Interaction of darunavir with this stable portion of the protease.
By Anonymous on 12/01/2019
种属： Human

Interaction of darunavir was studied with the stable portion of the protease. It was an attempt to finally identify interactions with HIV-1 protease and to be more resistant against HIV-1 protease mutations.

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