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Submit ReviewDavunetide
说明： Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo
别名： AL-108,NAP (peptide),NAPVSIPQ
纯度： ≥95% (HPLC)
生物活性 for Davunetide
Davunetide is a highly potent active component of activity-dependent neuroprotective protein (ADNP). Prevents β-amyloid aggregation. Reduces hyperphosphorylated tau levels and increases tau-microtubule interactions; neuroprotective at femtomolar concentrations in vitro. Exerts neuroprotective effects in schizophrenia models associated with microtubule-autophagy insufficiency in MAP6-deficient mice. Modulates HIFs and VEGF expression and suppresses retinal cell apoptosis in an in vivo diabetic retinopathy model.
技术数据 for Davunetide
| 分子量 | 824.93 |
| 公式 | C36H60N10O12 |
| 序列 | NAPVSIPQ |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 211439-12-2 |
| PubChem ID | 9832404 |
| InChI Key | DWLTUUXCVGVRAV-XWRHUKJGSA-N |
| Smiles | O=C(N[C@@H](C)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Davunetide
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Davunetide
参考文献 for Davunetide
参考文献是支持产品生物活性的出版物。
Bassan et al (1999) Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. J.Neurochem. 72 1283 PMID: 10037502
Gozes et al (2000) Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze J.Pharmacol.Exp.Ther. 293 1091 PMID: 10869414
Sragovich et al (2017) ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease. Bioessays 39 doi: 10.1002 PMID: 28940660
Melo et al (2017) Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease. Exp.Brain Res. 235 731 PMID: 27866262
D'Amico et al (2018) NAP counteracts hyperglycemia/hypoxia induced retinal pigment epithelial barrier breakdown through modulation of HIFs and VEGF expression. J.Cell Physiol. 233 1120 PMID: 28436035
Ivashko-Pachima et al (2017) ADNP/NAP dramatically increase microtubule end-binding protein-Tau interaction: a novel avenue for protection against tauopathy. Mol Psychiatry 22 1335 PMID: 28115743
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关键词: Davunetide, Davunetide supplier, AL-108, NAP, (peptide), NAPVSIPQ, Amyloid, Beta, Peptides, Microtubules, 6779, Tocris Bioscience
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.