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dCeMM2

Cat. No. 7525 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Molecular glue Degrader; induces ubiquitination and degradation of cyclin K
化学名： N-(5-Chloro-2-pyridinyl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for dCeMM2

dCeMM2 is a molecular glue degrader. Induces ubiquitination and degradation of cyclin K by eliciting an interaction of CDK12-cyclin K with a CRL4B ligase complex. dCeMM2 displays near-total degradation of protein at 2.5 μM within 2h. Cell-permeable.

技术数据 for dCeMM2

分子量 370.82
公式 C16H11ClN6OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 296771-07-8
PubChem ID 5286209
InChI Key VFWVTIHYVUKNGR-UHFFFAOYSA-N
Smiles O=C(NC1=NC=C(Cl)C=C1)CSC2=NN=C3C(NC4=C3C=CC=C4)=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for dCeMM2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.54 50

制备储备液 for dCeMM2

以下数据基于产品分子量 370.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.39 mL 26.97 mL 53.93 mL
2.5 mM 1.08 mL 5.39 mL 10.79 mL
5 mM 0.54 mL 2.7 mL 5.39 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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参考文献 for dCeMM2

参考文献是支持产品生物活性的出版物。

Mayor-Ruiz et al (2020) Rational discovery of molecular glue degraders via scalable chemical profiling. Nat.Chem.Biol. 16 1199 PMID: 32747809

If you know of a relevant reference for dCeMM2, please let us know.

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关键词: dCeMM2, dCeMM2 supplier, molecular, glue, degraders, degrades, cyclin, K, CDK12, CRL4B, ligase, DDB1, ubiquitination, proteasomal, degradation, Molecular, Glues, Transcriptional, CDKs, 7525, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

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