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Submit ReviewDecitabine
说明： DNA methyltransferase inhibitor
别名： 2'-Deoxy-5-azacytidine,5-Aza-2'-deoxycytidine,NSC 127716
化学名： 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
纯度： ≥99% (HPLC)
生物活性 for Decitabine
Decitabine is a cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.
For more information about how Decitabine may be used, see our protocol:
Highly Efficient Generation of CiPSCs from MEFs化合物库 for Decitabine
Decitabine is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Decitabine
| 分子量 | 228.21 |
| 公式 | C8H12N4O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 2353-33-5 |
| PubChem ID | 451668 |
| InChI Key | XAUDJQYHKZQPEU-KVQBGUIXSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(N)=NC2=O)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Decitabine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 11.41 | 50 | |
| DMSO | 11.41 | 50 |
制备储备液 for Decitabine
以下数据基于产品分子量 228.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 8.76 mL | 43.82 mL | 87.64 mL |
| 2.5 mM | 1.75 mL | 8.76 mL | 17.53 mL |
| 5 mM | 0.88 mL | 4.38 mL | 8.76 mL |
| 25 mM | 0.18 mL | 0.88 mL | 1.75 mL |
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产品说明书 for Decitabine
参考文献 for Decitabine
参考文献是支持产品生物活性的出版物。
Bender et al (1998) Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines. Cancer Res. 58 95 PMID: 9426064
Momparler (2005) Pharmacology of 5-aza-2'-deoxycytidine (decitabine). Semin.Hematol. 42 S9 PMID: 16015507
Jackson-Grusby et al (1997) Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase. Proc.Natl.Acad.Sci.USA 94 4681
If you know of a relevant reference for Decitabine, please let us know.
按产品操作查看相关产品
关键词: Decitabine, Decitabine supplier, DNA, methyltransferase, inhibitors, inhibits, Transferases, stem, cells, NSC127716, epigenetics, 5-Aza-2'-deoxycytidine, 2'-Deoxy-5-azacytidine, chemotherapeutics, NSC, 127716, Methyltransferases, 2624, Tocris Bioscience
6 篇 Decitabine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Decitabine 的部分引用包括：
Perera et al (2009) Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS One 4 e4488 PMID: 19221603
Wang et al (2012) Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. PLoS One 7 e39446 PMID: 22761798
Trowbridge et al (2012) Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. BMC Cancer 26 344 PMID: 22345515
Kottakis et al (2016) LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 390 PMID: 27799657
Vendetti et al (2015) Evaluation of azacit. and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer. Genes Dev 6 56 PMID: 25474141
Gu et al (2014) Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy. J Biol Chem 289 14881 PMID: 24695740
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Decitabine 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Decitabine?
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We got expected effect on cells.
By
Anonymous on 04/03/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： Primary pancreatic ductal epithelial cells
Cells were treated with 0.0015–30 μ decitabine
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Epigenetics in Cancer Research Product Guide
This product guide reviews some of the main areas in cancer epigenetics research and lists around 120 products that can be used for the main epigenetic targets including:
- Histone Methylation
- Histone Acetylation
- DNA Methylation
- Ubiquitination
- Bromodomains
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.