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Submit ReviewDexamethasone
说明： Anti-inflammatory glucocorticoid
化学名： (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
纯度： ≥98% (HPLC)
生物活性 for Dexamethasone
Dexamethasone is a glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors.
Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
化合物库 for Dexamethasone
Dexamethasone is also offered as part of the Tocriscreen Antiviral Library, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Dexamethasone
| 分子量 | 392.47 |
| 公式 | C22H29FO5 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 50-02-2 |
| PubChem ID | 9830630 |
| InChI Key | UREBDLICKHMUKA-WNYCSEIESA-N |
| Smiles | O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Dexamethasone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 39.25 | 100 |
制备储备液 for Dexamethasone
以下数据基于产品分子量 392.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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产品说明书 for Dexamethasone
参考文献 for Dexamethasone
参考文献是支持产品生物活性的出版物。
Matasic et al (1999) Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J.Leukoc.Biol. 66 909 PMID: 10614771
Sittichokechaiwut et al (2010) Short bouts of mechanical loading are as effective as dexameth. at inducing matrix production by human bone marrow mesenchymal stem cell. Eur.Cell Mater. 20 45 PMID: 20648425
Teixeira et al (1996) Effects of dexameth. and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig. Br.J.Pharmacol. 118 317 PMID: 8735633
Merck Index 12 2986
Laane et al (2009) Cell death induced by dexameth. in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 16 1018 PMID: 19390558
Huch et al (2015) Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 160 299 PMID: 25533785
Deng et al (2014) The effect of dexamethasone on lentiviral vector infection is associated with importin α. Biomed.Rep. 2 137 PMID: 24649085
Seregin et al (2009) Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy. Mol.Ther. 17 685 PMID: 19174760
If you know of a relevant reference for Dexamethasone, please let us know.
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关键词: Dexamethasone, Dexamethasone supplier, Anti-inflammatory, glucocorticoid, receptor, Receptors, induces, differentiation, liver, organoids, viral, transduction, enhancers, Glucocorticoid, Receptor, Autophagy, Mesenchymal, Stem, Cells, NF-kB/IkB, Organoids, Viral, Transduction, Enhancers, 1126, Tocris Bioscience
8 篇 Dexamethasone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Dexamethasone 的部分引用包括：
Peng et al (2018) Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell 175 1607 PMID: 30500539
Pinheiro et al (2016) Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res.Bull. 124 222 PMID: 27208730
Ibrahim et al (2018) Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and DEX Analgesia in an Animal Model of Low Back Pain. Front Cell Neurosci 12 453 PMID: 30524245
Carbone et al (2012) R.zole elevates GLT-1 activity and levels in striatal astrocytes. J Neurosci 60 42613 PMID: 22080156
Knutson et al (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One 9 e111840 PMID: 25493630
Bullers et al (2014) The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A 20 2390 PMID: 24548290
Sampaziotis et al (2017) Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc 12 814 PMID: 28333915
Segal et al (2019) Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. Nat Commun 10 3350 PMID: 31350390
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Dexamethasone 的评论
平均评分: 5 (基于 2 条评论。)
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Dexamethasone used in HUDEP-2 cell culture.
By
Anonymous on 12/11/2023
分析类型： In Vitro
种属： Human
细胞系/组织： HUDEP-2
Dexamethasone (Cat. No. 1126) was used in HUDEP-2 (erythroid progenitor cells) cell culture media. Image shows culture of the erythroid progenitor cell line HUDEP-2.
Great anti-inflammatory drug.
By
Luiz Alexandre Magno on 02/17/2022
分析类型： In Vivo
种属： Mouse
I used this drug to decrease the levels of IL-1, which is a proinflammatory cytokine. By doing this, we can explore the outcome of signalling pathways that can cause brain disease
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.