Dimebon dihydrochloride

Name: Dimebon dihydrochloride
Brand: Tocris Bioscience
SKU: 3201

Cat. No. 3201 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3201 has been discontinued.

说明： Neuroprotectant; protects against β-amyloid neurotoxicity

别名： Dimebone,Latrepirdine

化学名： 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

纯度： ≥98%

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Dimebon dihydrochloride

Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT₆ and 5-HT₇), α-adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Does not inhibit acetylcholinesterase activity. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β-amyloid fragment; shown to enhance autophagy in yeast and reduce intracellular Aβ42 levels.

技术数据 for Dimebon dihydrochloride

分子量	392.37
公式	C₂₁H₂₅N₃.2HCl
储存	Desiccate at RT
纯度	≥98%
CAS Number	97657-92-6
PubChem ID	23729232
InChI Key	GTWLIQOLGOZTLF-UHFFFAOYSA-N
Smiles	CC(N=C4)=CC=C4CCN2C1=CC=C(C)C=C1C3=C2CCN(C)C3.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Dimebon dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Dimebon dihydrochloride

参考文献是支持产品生物活性的出版物。

Bachurin et al (2001) Antihistamine agent dimebon as a novel neuroprotector and a cognitive enhancer. Ann.N.Y.Acad.Sci. 939 425 PMID: 11462798

Schaffhauser et al (2009) Dimebon is a 5-HT₆ antagonist with acute cognitive enhancing activities. Biochem.Pharmacol. 78 1035 PMID: 19549510

Okun et al (2009) From anti-allergic to anti-Alzheimer's: molecular pharmacology of dimebon. Curr.Alzheimer Res. 7 97

Giorgetti et al (2010) Cognition-enhancing properties of dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-MthD.-aspartate receptor antagonism J.Pharm.Exp.Ther. 333 748

Bharadwaj et al (2012) Latrepirdine (Dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. J.Alzheimers Dis. 32 949 PMID: 22903131

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