Dimethylenastron

Name: Dimethylenastron
Brand: Tocris Bioscience
SKU: 5261

Cat. No. 5261 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5261 has been discontinued.

View all Kinesin products.

说明： Inhibitor of mitotic motor kinesin Eg5

化学名： 2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Dimethylenastron

Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC₅₀ = 200 nM). Arrests mitosis, triggers apoptosis and up-regulates Hsp-70 expression in multiple human myeloma cell lines. Also inhibits the growth of several types of cancer cell lines (EC₅₀ values are 330, 603, 743 and 881 nM in HCT116, Htert-HME1, BxPC3, K562 and NCI-H1299 cancer cells, respectively). Suppresses the migration and invasion of PANC1 cells in vitro. Cytoprotective.

技术数据 for Dimethylenastron

分子量	302.39
公式	C₁₆H₁₈N₂O₂S
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	863774-58-7
PubChem ID	11609157
InChI Key	RUOOPLOUUAYNPY-UHFFFAOYSA-N
Smiles	O=C1CC(C)(C)CC2=C1C(C3=CC=CC(O)=C3)NC(N2)=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Dimethylenastron

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Dimethylenastron

参考文献是支持产品生物活性的出版物。

Kaan et al (2010) Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol. J.Med.Chem. 53 5676 PMID: 20597485

Liu et al (2006) Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells. J.Biol.Chem. 281 18090 PMID: 16627469

Sun et al (2011) Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. Acta.Pharmacol Sin. 32 1543 PMID: 21986572

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1 篇 Dimethylenastron 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Dimethylenastron 的部分引用包括：

Simon P et al (2021) Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. Elife 10 PMID: 34677124