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Diprotin A

Cat. No. 6019 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Dipeptidyl peptidase IV (DPP-IV) inhibitor
别名： Ile-Pro-Ile
化学名： L-Isoleucyl-L-prolyl-L-isoleucine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Diprotin A

Diprotin A is a dipeptidyl peptidase IV (DPP-IV) inhibitor. Inhibits hydrolysis of incretins, regulating blood glucose levels. Induces Src and vascular endothelium-cadherin phosphorylation, increasing vascular permeability in the retina. Also increases number of viable phenotypic long term repopulating hematopoietic stem cells when harvesting mouse bone marrow in aerobic conditions.

技术数据 for Diprotin A

分子量 341.45
公式 C17H31N3O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 90614-48-5
PubChem ID 94701
InChI Key JNTMAZFVYNDPLB-PEDHHIEDSA-N
Smiles O=C([C@@H](N)[C@@H](C)CC)N1[C@H](C(N[C@H](C(O)=O)[C@@H](C)CC)=O)CCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Diprotin A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 34.15 100

制备储备液 for Diprotin A

以下数据基于产品分子量 341.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.64 mL 29.29 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
10 mM 0.29 mL 1.46 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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产品说明书 for Diprotin A

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Diprotin A

参考文献是支持产品生物活性的出版物。

Juillerat-Jeanneret et al (2014) Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else? J.Med.Chem. 57 2197 PMID: 24099035

Lim et al (2015) Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation. Korean J.Intern.Med. 30 759 PMID: 26552451

Lee et al (2016) Dipeptidyl peptidase-4 inhibitor increases vascular leakage in retina through VE-cadherin phosphorylation. Sci.Rep. 6 29393 PMID: 27381080

If you know of a relevant reference for Diprotin A, please let us know.

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关键词: Diprotin A, Diprotin A supplier, dipeptidyl, peptidase, IV, DPP-IV, potent, selective, inhibitors, inhibits, type, 2, diabetes, hematopoietic, stem, cells, HSCs, vascular, permeability, DPP4, haematopoietic, HSC, Ile-Pro-Ile, Dipeptidyl, Peptidase, (DPP-IV), Stem, Cell, Proliferation, Hematopoietic, Cells, 6019, Tocris Bioscience

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