Dipeptidyl Peptidase IV
Dipeptidyl Peptidase IV (DPP-IV) (also known as CD26) is a ubiquitous, membrane-bound enzyme that has several roles including in nutrition, metabolism, bone marrow mobilization, cancer growth, cell adhesion and within both the immune and endocrine systems.
Dipeptidyl Peptidase IV Inhibitors |
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|---|---|
| Cat. No. | 产品名称/活性 |
| 6019 | Diprotin A |
| Dipeptidyl peptidase IV (DPP-IV) inhibitor | |
| 2783 | DPPI 1c hydrochloride |
| Dipeptidyl peptidase IV (DPP-IV) inhibitor | |
| 6507 | Saxagliptin hydrochloride |
| High affinity DPP-IV inhibitor; active in vivo | |
| 6816 | Sitagliptin phosphate |
| Potent and selective DPP IV inhibitor | |
| 3719 | Talabostat mesylate |
| Potent DPP IV inhibitor; activates NLRP1b inflammasome | |
Dipeptidyl Peptidase IV (DPP-IV) (also known as CD26) is a ubiquitous, membrane-bound enzyme that has roles in nutrition, metabolism, the immune and endocrine systems, bone marrow mobilization, cancer growth and cell adhesion.
DDP-IV catalyzes the hydrolysis of N-terminal dipeptides from polypeptides with proline or alanine in the penultimate position. This enzyme has many natural substrates including GLP-1, GIP, PACAP 38, NPY and GRP. DPP-IV exists as a homodimer and each monomer consists of two domains; an α/β hydrolase domain and an eight-blade β-propeller domain. DDP-IV binds to, but does not cleave, adenosine deaminase, kidney Na+/H+ ion exchanger and fibronectin, which localizes these molecules to the cell surface. A soluble form of DDP-IV does also exist, although it is only known to function in relation to T-cell proliferation. The human gene encoding DPP-IV is localized to chromosome 2q24.2.