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说明： TGF-β1 inhibitor
纯度： ≥95% (HPLC)
生物活性 for Disitertide
Disitertide is a transforming growth factor-beta 1 (TGF-β1) inhibitor. In vitro, it inactivates TGF-β1/Smads signaling which reduces cell migration and invasion without affecting cell proliferation in colorectal carcinoma cell lines (Lovo and SW480 cells).
技术数据 for Disitertide
| 分子量 | 1580.83 |
| 公式 | C68H109N17O22S2 |
| 序列 | TSLDASIIWAMMQN |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 272105-42-7 |
| PubChem ID | 9833838 |
| InChI Key | IUYPEUHIWDMJLM-SWHDLQTQSA-N |
| Smiles | O=C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Disitertide
参考文献 for Disitertide
参考文献是支持产品生物活性的出版物。
Wu et al (2021) LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway. Cell Death Differ. 28 219 PMID: 32737443
Yao et al (2019) Activation of Slit2/Robo1 signaling promotes tumor metastasis in colorectal carcinoma through activation of the TGF-β/Smads pathway. Cells 8 635 PMID: 31242633
Feng et al (2020) Degradation of intracellular TGF-beta 1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events. Chem.Commun. 56 2881 PMID: 32037404
Qi et al (2021) PROTAC: An effective targeted protein degradation strategy for cancer therapy. Front.Pharmacol. 12 692574 PMID: 34025443
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关键词: Disitertide, Disitertide supplier, TGF-βRI, TGF-β, TGF-betaRI, TGFbRI, TGFbR1, Kinases, Transforming, Growth, Factors, Beta, Receptors, TGF-beta, RSTK, Receptor, Serine/Threonine, RSTKs, 7717, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for Disitertide
