Doxycycline hyclate

Name: Doxycycline hyclate
Brand: Tocris Bioscience
SKU: 4090
Rating: 4 (1 reviews)

Cat. No. 4090 9 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Broad-spectrum MMP inhibitor; tetracycline derivative

化学名： (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate

纯度： ≥92% (HPLC)

说明书

引用文献 (9)

实验方案 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Doxycycline hyclate

Doxycycline hyclate is a broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Doxycycline hyclate increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems.

For more information about how Doxycycline hyclate may be used, see our protocols: Transdifferentiating Fibroblasts into Neurons, Reprogramming MEFs into Skeletal Muscle Progenitors.

技术数据 for Doxycycline hyclate

分子量	512.94
公式	C₂₂H₂₄N₂O₈.HCl.0.5C₂H₆O.0.5H₂O
储存	Store at +4°C
纯度	≥92% (HPLC)
CAS Number	24390-14-5
PubChem ID	54686183
InChI Key	UHHHTIKWXBRCLT-VDBOFHIQSA-N
Smiles	OC1=C(C(C2=C(O)[C@@](C(C(C(N)=O)=C(O)[C@H]4N(C)C)=O)(O)[C@@]4([H])[C@@H](O)[C@@]([H])2[C@H]3C)=O)C3=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Doxycycline hyclate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	48.09	100
	DMSO	48.09	100

制备储备液 for Doxycycline hyclate

以下数据基于产品分子量 512.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.75 mL	19.5 mL
5 mM	0.39 mL	1.95 mL	3.9 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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产品说明书 for Doxycycline hyclate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Doxycycline hyclate

参考文献是支持产品生物活性的出版物。

Franco et al (2006) Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices. Am.J.Pathol. 168 1697 PMID: 16651635

Burggraf et al (2007) Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol.Dis. 25 506 PMID: 17166729

Wernig et al (2008) A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat.Biotechnol. 26 916 PMID: 18594521

If you know of a relevant reference for Doxycycline hyclate, please let us know.

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关键词: Doxycycline hyclate, Doxycycline hyclate supplier, tetracycline, antibiotics, inhibits, MMPs, matrix, metalloprotease, metalloproteinase, inhibitors, Matrix, Metalloprotease, Antibiotics, 4090, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Doxycycline hyclate (internal use), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov