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DX3-213B

Cat. No. 8070 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent NDUFS7 antagonist
化学名： (4,4-Difluoro-1-piperidinyl)[(3R)-1-[[4-[(1-methylethyl)sulfonyl]phenyl]sulfonyl]-3-piperidinyl]methanone
纯度： ≥97% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DX3-213B

DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I (also known as NDUFS7) antagonist (IC50 = 3.6 nM). DX3-213B impairs ATP generation (IC50 = 11 nM) and inhibits the proliferation of MIA PaCa-2 cells (IC50 = 9 nM) in galactose-containing media. In vivo, DX3-213B significantly delays tumor growth in a syngeneic mouse model of pancreatic cancer. DX3-213B is orally bioavailable.

许可信息

Sold under license from the University of Michigan

技术数据 for DX3-213B

分子量 478.57
公式 C20H28F2N2O5S2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 2749555-66-4
PubChem ID 162365370
InChI Key HLSJMSNPBRGRGL-MRXNPFEDSA-N
Smiles O=S(N1C[C@H](C(N2CCC(CC2)(F)F)=O)CCC1)(C3=CC=C(S(C(C)C)(=O)=O)C=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DX3-213B

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.93 50

制备储备液 for DX3-213B

以下数据基于产品分子量 478.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.18 mL 20.9 mL 41.79 mL
2.5 mM 0.84 mL 4.18 mL 8.36 mL
5 mM 0.42 mL 2.09 mL 4.18 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

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参考文献 for DX3-213B

参考文献是支持产品生物活性的出版物。

Xu et al (2023) First-in-class NADH/Ubiquinone oxidoreductase core subunit S7 (NDUFS7) antagonist for the treatment of pancreatic cancer. ACS Pharmacol.Transl.Sci. 6 1164 PMID: 37588763

Xue et al (2022) Multiparameter optimization of oxidative phosphorylation inhibitors for the treatment of pancreatic cancer. J.Med.Chem. 65 3404 PMID: 35167303

If you know of a relevant reference for DX3-213B, please let us know.

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关键词: DX3-213B, DX3-213B supplier, OXPHOS, potent, orally, bioavailable, complex, 1, antogonist, oxidative, phosphorylation, pancreatic, cancer, in, vivo, NDUFS7, Oxidative, Phosphorylation, 8070, Tocris Bioscience

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