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E 2012

Cat. No. 5550 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： γ-secretase modulator; Notch-sparing
化学名： (3E)-1-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-2-piperidone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for E 2012

E 2012 is a γ-secretase modulator. Lowers Aβ40 and Aβ42 levels and increases Aβ37 levels, in vitro and in vivo. Displays no effect on γ-secretase processing of Notch, EphA4 and EphB2.

化合物库 for E 2012

E 2012 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for E 2012

分子量 419.49
公式 C25H26FN3O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 870843-42-8
PubChem ID 11560787
InChI Key PUOAETJYKQITMO-LANLRWRYSA-N
Smiles COC1=C(N2C=C(C)N=C2)C=CC(/C=C3CCCN([C@@H](C)C4=CC=C(F)C=C4)C\3=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for E 2012

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. HCl 41.95 100
DMSO 41.95 100

制备储备液 for E 2012

以下数据基于产品分子量 419.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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参考文献 for E 2012

参考文献是支持产品生物活性的出版物。

Borgegard et al (2012) First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. J.Biol.Chem. 287 15 PMID: 22334705

Portelius et al (2010) Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs. J.Alzheimers Dis. 21 1005 PMID: 20634579

If you know of a relevant reference for E 2012, please let us know.

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关键词: E 2012, E 2012 supplier, E2012, gamma, secretase, modulators, modulates, notch, sparing, Gamma-Secretase, 5550, Tocris Bioscience

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