E 7820

Cat. No. 6785 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： α₂ integrin inhibitor; anti-angiogenic

化学名： 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for E 7820

E 7820 is a α₂ integrin inhibitor. Inhibits angiogenesis in vitro (IC₅₀ = 0.11 - 0.25 μM). Also inhibits growth of human colorectal cancer cell lines. Enhances efficacy of erlotinib in a non-small-cell lung cancer xenograft model. Also acts as a molecular glue to induce proteosomal degradation of mRNA splicing factor RBM39.

化合物库 for E 7820

E 7820 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for E 7820

分子量	336.37
公式	C₁₇H₁₂N₄O₂S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	289483-69-8
PubChem ID	196970
InChI Key	LWGUASZLXHYWIV-UHFFFAOYSA-N
Smiles	CC1=C2C(C#N)=CNC2=C(C=C1)NS(=O)(C3=CC(C#N)=CC=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for E 7820

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	33.64	100

制备储备液 for E 7820

以下数据基于产品分子量 336.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.86 mL	29.73 mL
5 mM	0.59 mL	2.97 mL	5.95 mL
10 mM	0.3 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.3 mL	0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for E 7820

分析证书/产品说明书

化学品安全技术说明书

参考文献 for E 7820

参考文献是支持产品生物活性的出版物。

Funahashi et al (2002) Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin α2 subunit on endothelium. Cancer Res. 62 6116

Ito et al (2014) Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models. Cancer Sci. 105 1023 PMID: 24841832

Uehara et al (2017) Selective degradation of splicing factor CAPERα by anticancer sulfonamides. Nat.Chem.Biol. 13 675 PMID: 28437394

If you know of a relevant reference for E 7820, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Integrin Inhibitors

关键词: E 7820, E 7820 supplier, E7820, molecular, glue, targeted, protein, degradation, NSC719239, anti, angiogenesis, alpha2, integrin, inhibitors, inhibits, Integrins, Biochemicals, and, Molecular, Biology, Glues, 6785, Tocris Bioscience

篇 E 7820 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 E 7820 的引用文献。您是否知道使用了 Tocris E 7820 的优秀论文？请告知我们.

E 7820 的评论

目前没有该产品的评论。 Be the first to review E 7820 and earn rewards!

Have you used E 7820?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.