Eact

Cat. No. 4876 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Activator of Ca²⁺-activated Cl^- channel transmembrane protein 16A (TMEM16A)

化学名： 3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide

纯度： ≥98% (HPLC)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Eact

Eact is a TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC₅₀ = 3 μM). Also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC₅₀ = 11.6 μM). Ca²⁺-independent. Displays no effect on CFTR Cl^- or ENaC Na⁺ conductance. Stimulates submucosal gland secretion in human bronchi.

化合物库 for Eact

Eact is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Eact

分子量	428.5
公式	C₂₂H₂₄N₂O₅S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	461000-66-8
PubChem ID	3173542
InChI Key	ZUXNHFFVQWADJL-UHFFFAOYSA-N
Smiles	O=C(C3=CC(OC)=C(OC)C(OC)=C3)N(CCOC)C1=NC(C2=CC=CC=C2)=CS1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Eact

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	42.85	100

制备储备液 for Eact

以下数据基于产品分子量 428.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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产品说明书 for Eact

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Eact

参考文献是支持产品生物活性的出版物。

Namkung et al (2011) Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J. 25 4048 PMID: 21836025

Liu et al (2016) Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br.J.Pharmacol. 173 1208 PMID: 26756551

If you know of a relevant reference for Eact, please let us know.

按标靶查看相关产品

关键词: Eact, Eact supplier, TMEM16A, ANO1, calcium-activated, chloride, channels, CaCC, activators, activates, anoctamin-1, submucosal, secretion, Ca2+-Activated, Chloride, Channels, TRPV, 4876, Tocris Bioscience

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