EGCG

Cat. No. 4524 11 篇引用文献 3 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： β-secretase (BACE) inhibitor; inhibits amyloid assembly

别名： Epigallocatechin gallate

化学名： 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

纯度： ≥98% (HPLC)

说明书

引用文献 (11)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for EGCG

EGCG is a β-secretase (BACE1) inhibitor (IC₅₀ = 1.6 μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate dehydrogenase. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.

技术数据 for EGCG

分子量	458.37
公式	C₂₂H₁₈O₁₁
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	989-51-5
PubChem ID	65064
InChI Key	WMBWREPUVVBILR-WIYYLYMNSA-N
Smiles	O=C(C4=CC(O)=C(O)C(O)=C4)O[C@@H]2CC1=C(O)C=C(O)C=C1O[C@@H]2[C@]3=CC(O)=C(O)C(O)=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EGCG

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	4.58	10
	DMSO	45.84	100

制备储备液 for EGCG

以下数据基于产品分子量 458.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.91 mL	21.82 mL
5 mM	0.44 mL	2.18 mL	4.36 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for EGCG

分析证书/产品说明书

化学品安全技术说明书

参考文献 for EGCG

参考文献是支持产品生物活性的出版物。

Jeon et al (2003) Green tea catechins as a BACE1 (β-secretase) inhibitor. Bioorg.Med.Chem.Lett. 13 3905 PMID: 14592472

Sinha et al (2012) Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem.Neurosci. 3 451 PMID: 22860214

Ahmad et al (2000) Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells. Ach.Biochem.Biophys. 376 338 PMID: 10775421

Shankar et al (2008) EGCG inhibits growth, invasion, angiogenesis and metastastasis of pancreatic cancer. Front.Biosci. 13 440 PMID: 17981559

Lee et al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018 PMID: 16037419

Yang et al (2009) Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 69 7986 PMID: 19826036

If you know of a relevant reference for EGCG, please let us know.

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