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EIDD 1931

Cat. No. 7231 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleoside
化学名： N-Hydroxycytidine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for EIDD 1931

EIDD 1931 is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. Inhibits replication of a range of RNA viruses including influenza, Ebola, HCV, and human and zoonotic coronaviruses (IC50 values are 0.15 and 0.3 μM for inhibition of MERS-CoV and SARS-CoV-2 replication in vitro). Increases mutation rates and induces lethal mutagenesis in viral RNA. Also inhibits replication of mouse hepatitis virus with mutations conferring resistance to remdesivir (Cat. No. 7226).

化合物库 for EIDD 1931

EIDD 1931 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for EIDD 1931

分子量 259.22
公式 C9H13N3O6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 3258-02-4
PubChem ID 197020
InChI Key XCUAIINAJCDIPM-XVFCMESISA-N
Smiles OC[C@H]1O[C@@H](N2C=C/C(NC2=O)=N\O)[C@@H]([C@@H]1O)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EIDD 1931

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.92 100
water 12.96 50

制备储备液 for EIDD 1931

以下数据基于产品分子量 259.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.29 mL 38.58 mL
5 mM 0.77 mL 3.86 mL 7.72 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for EIDD 1931

参考文献是支持产品生物活性的出版物。

Urakova et al (2018) β-d-N4-hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome. J.Virol. 92 PMID: 29167335

Sheahan et al (2020) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci.Transl.Med. 12 PMID: 32253226

If you know of a relevant reference for EIDD 1931, please let us know.

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关键词: EIDD 1931, EIDD 1931 supplier, EIDD1931, NHC, antiviral, RdRP, RNA, dependent, polymerase, inhibitors, inhibits, broad, spectrum, coronavirus, nucleoside, Polymerase, Non-selective, Antivirals, Coronavirus, 7231, Tocris Bioscience

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