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说明： eIF4A inhibitor
化学名： 2-(5-(4-Butylphenyl)furan-2-yl)-6-nitroquinoline-4-carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for eIF4A i28
eIF4A i28 is a eukaryotic initiation factor-4A (eIF4A) inhibitor (IC50 = 8.60 μM in an eIF4A ATPase assay). It decreases BJAB Burkitt lymphoma cell viability (EC50 = 0.46 μM in a CellTiter-Glo (CTG) luminescence cell viability assay. It acts as an RNA-competitive, ATP-uncompetitive eIF4A inhibitor.
许可信息
Sold under license from the University of Arizona
技术数据 for eIF4A i28
| 分子量 | 416.43 |
| 公式 | C24H20N2O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2861994-92-3 |
| PubChem ID | 163198549 |
| InChI Key | UDCAKLDMNJRQKW-UHFFFAOYSA-N |
| Smiles | CCCCC1=CC=C(C2=CC=C(C3=NC4=CC=C(C=C4C(C(O)=O)=C3)[N+]([O-])=O)O2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for eIF4A i28
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 8.33 | 20 |
制备储备液 for eIF4A i28
以下数据基于产品分子量 416.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.01 mL | 60.03 mL | 120.07 mL |
| 1 mM | 2.4 mL | 12.01 mL | 24.01 mL |
| 2 mM | 1.2 mL | 6 mL | 12.01 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
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产品说明书 for eIF4A i28
参考文献 for eIF4A i28
参考文献是支持产品生物活性的出版物。
Zerio et al (2021) Discovery of an eIF4A inhibitor with a novel mechanism of action. J.Med.Chem. 64 15727 PMID: 34676755
If you know of a relevant reference for eIF4A i28, please let us know.
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关键词: eIF4A i28, eIF4A i28 supplier, eIF4Ai28, eIF4A, lymphoma, cell, viability, RNA, competitive, RNA-competitive, inhibitor, inhibits, ATP-uncompetitive, DNA,, and, Protein, Synthesis, 7810, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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