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Submit ReviewEletriptan hydrobromide
说明： 5-HT1B and 5-HT1D agonist; orally active
化学名： 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole hydrobromide
纯度： ≥99% (HPLC)
生物活性 for Eletriptan hydrobromide
Orally active, selective 5-HT1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo. Displays antimigraine activity.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for Eletriptan hydrobromide
Eletriptan hydrobromide is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Eletriptan hydrobromide
| 分子量 | 463.43 |
| 公式 | C22H26N2O2S.HBr |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 177834-92-3 |
| PubChem ID | 656631 |
| InChI Key | UTINOWOSWSPFLJ-FSRHSHDFSA-N |
| Smiles | CN1[C@@H](CC3=CNC2=CC=C(CCS(=O)(C4=CC=CC=C4)=O)C=C23)CCC1.Br |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Eletriptan hydrobromide
参考文献 for Eletriptan hydrobromide
参考文献是支持产品生物活性的出版物。
Napier et al (1999) Characterisation of the 5-HT receptor binding profile of eletr. and kinetics of [3H]-eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur.J.Pharmacol. 368 259 PMID: 10193663
Gupta et al (2000) The in vivo pharmacological profile of eletr. (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur.J.Pharmacol. 398 73 PMID: 10856450
Willems et al (1998) Porcine carotid vascular effects of eletr. (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn-Schmied.Arch.Pharmacol. 358 212
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关键词: Eletriptan hydrobromide, Eletriptan hydrobromide supplier, 5-HT1B, 5-HT1D, 5-HT1B/1D, selective, orally, active, agonists, receptors, serotonin, Pfizer, Receptors, 3862, Tocris Bioscience
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