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EM 12-FS

Cat. No. 7851 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Molecular glue; induces degradation of NQAT1
别名： Selective NTAQ1 degrader
化学名： 3-[6-[(Fluorosulfonyl)oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
纯度： ≥95% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for EM 12-FS

EM12-FS is a selective N-terminal glutamine amidohydrolase 1 (NTAQ1) Degrader. In MOLT4 cells, it downregulates NTAQ1 via cereblon-mediated degradation (IC50 = 256 nM). Requires covalent His353 engagement to recruit and degrade NTAQ1.

技术数据 for EM 12-FS

分子量 342.3
公式 C13H11FN2O6S
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2839138-44-0
PubChem ID 165879822
InChI Key RXYXBYLQECASPH-UHFFFAOYSA-N
Smiles O=C1NC(C(CC1)N2C(C3=CC(OS(=O)(F)=O)=CC=C3C2)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EM 12-FS

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.23 100

制备储备液 for EM 12-FS

以下数据基于产品分子量 342.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.61 mL 29.21 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for EM 12-FS

参考文献是支持产品生物活性的出版物。

Cruite et al (2022) Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem.Biol. 3 1105 PMID: 36128501

If you know of a relevant reference for EM 12-FS, please let us know.

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关键词: EM 12-FS, EM 12-FS supplier, EM12-FS, selective, inhibitors, inhibits, active, degraders, degrades, PROTAC, PROTACs, targeted, protein, degradation, tpd, N-terminal, glutamine, amidohydrolase, 1, NTAQ1, Selective, degrader, Other, Hydrolases, Molecular, Glues, 7851, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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