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Submit Reviewent-LP 99
说明： Negative Control for LP 99
化学名： N-[(2S,3R)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide
纯度： ≥98% (HPLC)
生物活性 for ent-LP 99
ent-LP 99 is a negative Control for LP 99 (Cat.No. 5496).
许可信息
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the ent-LP 99 probe summary on the SGC website.
化合物库 for ent-LP 99
ent-LP 99 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for ent-LP 99
| 分子量 | 516.05 |
| 公式 | C26H30ClN3O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1808948-28-8 |
| Smiles | CC(C(C=C1)=C(N2C)C=C1N3[C@@H](C4=CC=C(Cl)C=C4)[C@H](NS(=O)(CC(C)C)=O)CCC3=O)=CC2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ent-LP 99
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 51.6 | 100 | |
| ethanol | 51.6 | 100 |
制备储备液 for ent-LP 99
以下数据基于产品分子量 516.05。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.94 mL | 9.69 mL | 19.38 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.88 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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产品说明书 for ent-LP 99
参考文献 for ent-LP 99
参考文献是支持产品生物活性的出版物。
Clark et al (2015) LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor. Angew.Chem.Int.Ed.Engl. 54 6217 PMID: 25864491
If you know of a relevant reference for ent-LP 99, please let us know.
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关键词: ent-LP 99, ent-LP 99 supplier, ent-LP99, selective, BRD7, BRD9, bromodomain, inhibitors, inhibits, negative, control, Bromodomains, 5497, Tocris Bioscience
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
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