主页 / 药理学 / Enzymes / Kinases / Mnk / Mnk Inhibitors / ETP 45835 dihydrochloride

ETP 45835 dihydrochloride

Cat. No. 5183 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5183 has been discontinued.

View all Mnk products.
说明： Mnk1 and Mnk2 inhibitor
化学名： 4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]pyridine dihydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for ETP 45835 dihydrochloride

ETP 45835 dihydrochloride is a Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.

技术数据 for ETP 45835 dihydrochloride

分子量 301.21
公式 C13H16N4.2HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 2136571-30-5
PubChem ID 71755761
InChI Key ASYCTHXAPLLLSZ-UHFFFAOYSA-N
Smiles C1(C2=CC(C3=CC=NC=C3)=NN2)CCNCC1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for ETP 45835 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for ETP 45835 dihydrochloride

参考文献是支持产品生物活性的出版物。

Oyarzabal et al (2010) Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 53 6618 PMID: 20722422

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Mnk Inhibitors

关键词: ETP 45835 dihydrochloride, ETP 45835 dihydrochloride supplier, ETP45835, dihydrochloride, mitogen-activated, protein, kinase-interacting, kinase, Mnk1, Mnk2, inhibitors, inhibits, [791852-46-5], Mnk, 5183, Tocris Bioscience

1 篇 ETP 45835 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ETP 45835 dihydrochloride 的部分引用包括：

Ichiyanagi et al (2019) Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma. Oncotarget 10 4053 PMID: 31258849

ETP 45835 dihydrochloride 的评论

目前没有该产品的评论。 Be the first to review ETP 45835 dihydrochloride and earn rewards!

Have you used ETP 45835 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.