Ex 26

Cat. No. 5833 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective S1P₁ receptor antagonist

化学名： 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid

纯度： ≥98% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ex 26

Ex 26 is a potent and selective S1P₁ receptor antagonist (IC₅₀ = 0.93 nM). Exhibits > 3,000-fold selectivity for S1P₁ over S1P₂, S1P₃, S1P₄ and S1P₅. Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P₁ receptor expression. Reduces disease severity in mice with EAE. Increases IFN-α production in stimulated dendritic cells in vivo.

化合物库 for Ex 26

Ex 26 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Ex 26

分子量	494.98
公式	C₂₈H₂₈ClFN₂O₃
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1233332-37-0
PubChem ID	59393740
InChI Key	YVHNBORUVLWCKF-UHFFFAOYSA-N
Smiles	CC(C1=CC(C)=C(C=C1)Cl)NC2=CC=C(C(C3=CC(C)=C(C(C)=C3)C(NC4(C(O)=O)CC4)=O)=C2)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ex 26

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	49.5	100
	ethanol	49.5	100

制备储备液 for Ex 26

以下数据基于产品分子量 494.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.1 mL	20.2 mL
5 mM	0.4 mL	2.02 mL	4.04 mL
10 mM	0.2 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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产品说明书 for Ex 26

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ex 26

参考文献是支持产品生物活性的出版物。

Teijaro et al (2016) S1PR₁-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell IF.-a autoamplification. Proc.Natl.Acad.Sci.U.S.A. 113 1351 PMID: 26787880

Cahalan et al (2013) Sphingosine 1-phosphate receptor 1 (S1P₁) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P₁ antagonist. Mol.Pharmacol. 83 316 PMID: 23204443

Kleinwort et al (2018) S1P signalling differentially affects migration of peritoneal B cell populations in vitro and influences the production of intestinal IgA in vivo. Int.J.Mol.Sci. 19 E391 PMID: 29382132

If you know of a relevant reference for Ex 26, please let us know.

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Sphingosine-1-Phosphate Receptors

关键词: Ex 26, Ex 26 supplier, Ex26, sphingosine-1-phosphate, S1P1, S1P1R, antagonists, antagonism, selective, Sphingosine-1-phosphate, Receptors, 5833, Tocris Bioscience