Fatostatin A

Cat. No. 4444 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cell permeable inhibitor of SREBP activation

化学名： 4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide

纯度： ≥97% (HPLC)

引用文献 (7)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Fatostatin A

Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC₅₀ = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.

化合物库 for Fatostatin A

Fatostatin A is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Fatostatin A

分子量	375.33
公式	C₁₈H₁₈N₂S.HBr
储存	Store at +4°C
纯度	≥97% (HPLC)
CAS Number	298197-04-3
PubChem ID	2850562
InChI Key	RJCFNQZVFUMORB-UHFFFAOYSA-N
Smiles	CCCC1=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=CC=N1.Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Fatostatin A

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	7.51	20

制备储备液 for Fatostatin A

以下数据基于产品分子量 375.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	13.32 mL	66.61 mL	133.22 mL
1 mM	2.66 mL	13.32 mL	26.64 mL
2 mM	1.33 mL	6.66 mL	13.32 mL
10 mM	0.27 mL	1.33 mL	2.66 mL

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产品说明书 for Fatostatin A

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Fatostatin A

参考文献是支持产品生物活性的出版物。

Kamisuki et al (2009) A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem.Biol. 16 882 PMID: 19716478

Choi et al (2003) Identification of bioactive molecules by adipogenesis profiling of organic compounds. J.Biol.Chem. 278 7320 PMID: 12496288

If you know of a relevant reference for Fatostatin A, please let us know.

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关键词: Fatostatin A, Fatostatin A supplier, sterol, regulatory, element, binding, proteins, SREBPs, SREBP1, SREBP2, inhibition, inhibitors, inhibits, antiproliferatives, 125B11, FatostatinA, SREBP, 4444, Tocris Bioscience

7 篇 Fatostatin A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Fatostatin A 的部分引用包括：

Keith S et al (2021) Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production. Sci Rep 11 16347 PMID: 34381163

Uma Kant et al (2015) Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses. J Biol Chem 290 9571-87 PMID: 25720493

Csaba et al (2019) Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs. Cell Stem Cell 25 120-136.e10 PMID: 31155483

Tania et al (2019) The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair. Immunity 51 241-257.e9 PMID: 31303399

Almut et al (2020) mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis. Cell Rep 31 107806 PMID: 32579932

Xuejun et al (2020) Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis. Proc Natl Acad Sci U S A 117 31189-31197 PMID: 33229547

Roche et al (2018) Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol 217 3560 PMID: 30054450

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Pathways for Fatostatin A

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.