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Favipiravir

Cat. No. 7225 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Viral RNA polymerase inhibitor
别名： T 705
化学名： 6-Fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Favipiravir

Favipiravir is a viral RNA polymerase inhibitor; exhibits no effects on mammalian RNA polymerase. Prodrug that is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5'-triphosphate (RTP). Reduces infection rate of SARS-CoV-2 in Vero E6 cells in vitro (IC50 = 61.88 μM). Inhibits influenza virus RNA-dependent RNA polymerase (RdRP) activity (IC50 = 341 nM). Induces lethal mutagenesis in MDCK cells inoculated with seasonal influenza A (H1N1) viruses. Protects mice against Ebola virus.

化合物库 for Favipiravir

Favipiravir is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Favipiravir

分子量 157.1
公式 C5H4FN3O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 259793-96-9
PubChem ID 492405
InChI Key ZCGNOVWYSGBHAU-UHFFFAOYSA-N
Smiles NC(C1=NC(F)=CNC1=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Favipiravir

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 15.71 100
ethanol 3.14 20

制备储备液 for Favipiravir

以下数据基于产品分子量 157.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 6.37 mL 31.83 mL 63.65 mL
5 mM 1.27 mL 6.37 mL 12.73 mL
10 mM 0.64 mL 3.18 mL 6.37 mL
50 mM 0.13 mL 0.64 mL 1.27 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Favipiravir

参考文献是支持产品生物活性的出版物。

Wang et al (2020) Remdesivir and Chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30 269 PMID: 32020029

Furuta et al (2002) In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob.Agents Chemother. 46 977 PMID: 11897578

If you know of a relevant reference for Favipiravir, please let us know.

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关键词: Favipiravir, Favipiravir supplier, T705, Viral, RNA, polymerase, inhibitors, inhibits, antiviral, influenza, ebola, covid-19, T, 705, Polymerase, Influenza, Viruses, Coronavirus, 7225, Tocris Bioscience

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