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FCCP

Cat. No. 0453 12 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Oxidative phosphorylation uncoupler
化学名： Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
纯度： ≥99% (HPLC)
说明书
引用文献 (12)
评论 (2)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FCCP

FCCP is a very potent uncoupler of oxidative phosphorylation in mitochondria.

技术数据 for FCCP

分子量 254.17
公式 C10H5F3N4O
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 370-86-5
PubChem ID 3330
InChI Key BMZRVOVNUMQTIN-UHFFFAOYSA-N
Smiles N#CC(C#N)=NNC1=CC=C(OC(F)(F)F)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FCCP

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.42 100

制备储备液 for FCCP

以下数据基于产品分子量 254.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.34 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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产品说明书 for FCCP

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for FCCP

参考文献是支持产品生物活性的出版物。

Connop et al (1999) Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J.Neurochem. 72 1457 PMID: 10098849

Heytler and Pritchard (1962) A new class of uncoupling agents - carbonyl cyanide phenylhydrazones. Biochem.Biophys.Res.Commun. 7 272 PMID: 13907155

If you know of a relevant reference for FCCP, please let us know.

按标靶查看相关产品

关键词: FCCP, FCCP supplier, Oxidative, phosphorylation, uncoupler, Phosphorylation, 0453, Tocris Bioscience

12 篇 FCCP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 FCCP 的部分引用包括：

MacDonald et al (2018) Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5. J Ovarian Res 11 89 PMID: 30326924

Rozzi et al (2018) Human immunodeficiency virus Tat impairs mitochondrial fission in neurons. Cell Death Discov 4 8 PMID: 29531805

Gerich et al (2009) H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus. J Pharmacol Exp Ther 458 937 PMID: 19430810

Choubey et al (2014) BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy 10 1105 PMID: 24879156

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FCCP 的评论

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We got expected effect on cells.
By Anonymous on 04/03/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： Primary pancreatic ductal epithelial cells

4 μM FCCP

review image
Mitochondrial bioenergetics measurements by reagent screen.
By Anonymous on 03/15/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： mouse brain endothelioma cell line

1 μM

PMID: 27978828
review image

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