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Submit ReviewFendiline Hydrochloride
说明： Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker
化学名： N-(3,3-Diphenylpropyl)-α-methylbenzylamine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Fendiline Hydrochloride
Fendiline Hydrochloride is a K-Ras inhibitor. Selectively inhibits K-Ras localization to the plasma membrane (IC50 = 9.64 μM). Blocks proliferation of cancer cell lines expressing oncogenic mutant K-Ras. Also inhibits L-type calcium channels (IC50 = 17 μM).
化合物库 for Fendiline Hydrochloride
Fendiline Hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Fendiline Hydrochloride
| 分子量 | 351.91 |
| 公式 | C23H25N.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 13636-18-5 |
| PubChem ID | 5702162 |
| InChI Key | NJXWZWXCHBNOOG-UHFFFAOYSA-N |
| Smiles | CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2)C3=CC=CC=C3.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Fendiline Hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 35.19 | 100 | |
| ethanol | 7.04 | 20 |
制备储备液 for Fendiline Hydrochloride
以下数据基于产品分子量 351.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.21 mL | 28.42 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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产品说明书 for Fendiline Hydrochloride
参考文献 for Fendiline Hydrochloride
参考文献是支持产品生物活性的出版物。
Tripathi et al (1993) Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study. Br.J.Pharmacol. 108 865 PMID: 8485628
van der Hoeven et al (2015) Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol.Cell.Biol. 33 237 PMID: 23129805
If you know of a relevant reference for Fendiline Hydrochloride, please let us know.
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关键词: Fendiline Hydrochloride, Fendiline Hydrochloride supplier, K-Ras, membrane, localization, inhibitors, inhibits, L-type, calcium, channel, Ca2+, voltage-gated, Cav, blockers, blocks, Cav1.x, Channels, Ras, GTPases, 6407, Tocris Bioscience
1 篇 Fendiline Hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Fendiline Hydrochloride 的部分引用包括：
Ting-Xin et al (2021) Global feather orientations changed by electric current. iScience 24 102671 PMID: 34179734
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
RAS Oncoproteins Scientific Review
Written by Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der, this review provides a comprehensive overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutic vulnerabilities are explored. This review also includes a detailed section on RAS drug discovery and targeting synthetic lethal interactors of mutant RAS. Compounds available from Tocris are listed.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Pathways for Fendiline Hydrochloride
Akt Signaling Pathway
The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.