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Flufenamic acid

Cat. No. 4522 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
化学名： 2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Flufenamic acid

Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.

技术数据 for Flufenamic acid

分子量 281.23
公式 C14H10F3NO2
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 530-78-9
PubChem ID 3371
InChI Key LPEPZBJOKDYZAD-UHFFFAOYSA-N
Smiles O=C(C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CC=C1)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Flufenamic acid

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.12 100
ethanol 28.12 100

制备储备液 for Flufenamic acid

以下数据基于产品分子量 281.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.56 mL 17.78 mL 35.56 mL
5 mM 0.71 mL 3.56 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.56 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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产品说明书 for Flufenamic acid

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Flufenamic acid

参考文献是支持产品生物活性的出版物。

Tu et al (2009) Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons. J.Neurochem. 108 126 PMID: 19094061

Foster et al (2009) Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. Cell Calcium 45 384 PMID: 19232718

Chi et al (2011) Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase. J.Pharmacol.Exp.Ther. 339 257 PMID: 21765041

White and Aylwin (1990) Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. Mol.Pharmacol. 37 720 PMID: 1692608

If you know of a relevant reference for Flufenamic acid, please let us know.

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关键词: Flufenamic acid, Flufenamic acid supplier, nsaids, antiinflammatories, antiinflammatory, Flufenamic, acid, activates, trpc6, agonists, Cyclooxygenase, TRPC, Ca2+-Activated, Chloride, Channels, 4522, Tocris Bioscience

3 篇 Flufenamic acid 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Flufenamic acid 的部分引用包括：

Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792

Ute et al (2022) Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers. Exp Dermatol 31 1477-1499 PMID: 35913427

O'Malley et al (2020) TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations J Neurosci 40 4813 PMID: 32414784

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Flufenamic acid 的评论

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Flufenamic Acid interaction with AKR1C4 protein was measured.
By Anonymous on 08/26/2019
种属： Human

Flufenamic Acid interaction with AKR1C4 protein was measured. The activity relation pattern observed.

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