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Discontinued Product
4495 has been discontinued.
说明： γ-secretase inhibitor; lowers Aβ42 levels in vitro
别名： (R)-Flurbiprofen
化学名： (R)-2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic acid
纯度： ≥99% (HPLC)
生物活性 for Flurizan
Nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.
技术数据 for Flurizan
| 分子量 | 244.26 |
| 公式 | C15H13FO2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 51543-40-9 |
| PubChem ID | 92337 |
| InChI Key | SYTBZMRGLBWNTM-SNVBAGLBSA-N |
| Smiles | FC1=C(C2=CC=CC=C2)C=CC([C@@H](C)C(O)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Flurizan
参考文献 for Flurizan
参考文献是支持产品生物活性的出版物。
Eriksen et al (2003) NSAIDs and enantiomers of flurbip. target γ-secretase and lower Aβ42 in vivo. J.Clin.Invest. 112 440 PMID: 12897211
Kukar et al (2007) Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 8 54 PMID: 17650315
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关键词: Flurizan, Flurizan supplier, NSAIDs, gamma, secretase, inhibitors, inhibits, AB42, beta, amyloid, flurbiprofen, tarenflurbil, R-flurbiprofen, Aβ42, and, Abeta42, gamma-secretase, amyloidbeta, amyloidb, amyloidβ, (R)-Flurbiprofen, Gamma-Secretase, Amyloid, Beta, Peptides, 4495, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
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- Organoid Generation
- GMP and Ancillary Material Grade Products
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.