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Submit ReviewFlutax 1
说明： Green-fluorescent taxol derivative; binds microtubules. Used for: imaging microtubules in live cells. Application: Fluorescent microscopy
化学名： (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine
纯度： ≥95% (HPLC)
生物活性 for Flutax 1
Key information: Flutax 1 is a green-fluorescent taxol derivative; for microtubules labeling in live cells.
Used for: direct imaging of the microtubule cytoskeleton.
Application: fluorescent microscopy.
Properties and Photophysical Data: Flutax 1 binds microtubules with high affinity (Ka ~ 107M-1). Absorption, fluorescence and fluorescence decay of Flutax 1 in solution are pH sensitive. Excitation and emission maxima (λ) are 495 nm and 520 nm, respectively.
Scientific Data
Flutax 1 labeled HeLa cells. Flutax 1 was diluted in HBSS and applied to live HeLa cells at a concentration of 2 μM. HeLa cells were incubated for 1 hour at 37°C. After incubation was complete, Flutax 1 was washed off, and fresh HBSS was applied to the cells. Cells were not fixed because Flutax 1 staining is not retained at all after fixation (photobleach). Staining can be done only on Live cells. Flutax 1 staining in live cells diminishes very rapidly when exposed to light, so the cells should be exposed to light as little as possible to retain good fluorescent signal.
技术数据 for Flutax 1
| 分子量 | 1283.3 |
| 公式 | C71H66N2O21 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 191930-58-2 |
| PubChem ID | 16760423 |
| InChI Key | JMWJJMCMRRQCSY-ADONSEPTSA-N |
| Smiles | O=C2[C@@]3(C)C([C@@]4(OC(C)=O)[C@H](OC4)C[C@@H]3OC([C@H](C)NC(C7=CC=C(C8=C(C=C%10)C(OC9=C8C=CC(O)=C9)=CC%10=O)C(C(O)=O)=C7)=O)=O)[C@H](OC(C6=CC=CC=C6)=O)[C@@]1(O)[C@](C)(C)C([C@H]2OC(C)=O)=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(C%11=CC=CC=C%11)=O)=O)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Flutax 1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 128.33 | 100 | |
| ethanol | 128.33 | 100 |
制备储备液 for Flutax 1
以下数据基于产品分子量 1283.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.78 mL | 3.9 mL | 7.79 mL |
| 5 mM | 0.16 mL | 0.78 mL | 1.56 mL |
| 10 mM | 0.08 mL | 0.39 mL | 0.78 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.16 mL |
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产品说明书 for Flutax 1
参考文献 for Flutax 1
参考文献是支持产品生物活性的出版物。
Diaz et al (2000) Molecular recognition of Tax. by microtubules. Kinetics and thermodynamics of binding of fluorescent Tax. derivatives to an exposed site. J.Biol.Chem. 275 26265 PMID: 10818101
Diaz et al (2003) Fast kinetics of Tax. binding to microtubules. J.Biol.Chem. 278 8407 PMID: 12496245
Evangelio et al (1998) Fluorescent taxoids as probes of the microtubule cytoskeleton. Cell Motil.Cytoskel. 39 73 PMID: 9453715
If you know of a relevant reference for Flutax 1, please let us know.
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关键词: Flutax 1, Flutax 1 supplier, Fluorescent, taxol, derivative, Mitosis, Probes, Tau, Tubulin, Microtubules, stain, tubulin, staining, Flutax1, oregon, green, Organelle, and, Cell, Structure, Stains, Microtubule, 2226, Tocris Bioscience
2 篇 Flutax 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Flutax 1 的部分引用包括：
Kaittanis et al (2014) Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nat Commun 5 3384 PMID: 24594970
Kaittanis et al (2015) Multifunctional MRI/PET Nanobeacons Derived from the in Situ Self-Assembly of Translational Polymers and Clinical Cargo through Coalescent Intermolecular Forces. Nano Lett 15 8032 PMID: 26540670
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Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
- Fluorescent Dyes, including dyes for flow cytometry
- Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
- Tissue Clearing Kits and Reagents
- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
- TSA Reagents for Enhancing IHC, ICC & FISH Signals