主页 / 细胞生物学 / Extracellular Matrix and Adhesion Molecules / RAGE / RAGE Antagonists / FPS ZM1

FPS ZM1

Cat. No. 6237 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity antagonist of RAGE
化学名： 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FPS ZM1

FPS ZM1 is a high affinity antagonist of the receptor for advanced glycation end products (RAGE) (Ki = 25 nM). Blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. Blocks β-secretase activity, Aβ production, microglia activation and neuroinflammation in vivo. BBB permeable.

化合物库 for FPS ZM1

FPS ZM1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for FPS ZM1

分子量 327.85
公式 C20H22ClNO
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 945714-67-0
PubChem ID 24752728
InChI Key XDFKWGIBQMHSOH-UHFFFAOYSA-N
Smiles ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FPS ZM1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.78 100
ethanol 32.78 100

制备储备液 for FPS ZM1

以下数据基于产品分子量 327.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.25 mL 30.5 mL
5 mM 0.61 mL 3.05 mL 6.1 mL
10 mM 0.31 mL 1.53 mL 3.05 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for FPS ZM1

参考文献是支持产品生物活性的出版物。

Deane et al (2012) A multimodal RAGE-specific inhibitor reduces amyloid beta -mediated brain disorder in a mouse model of Alzheimer disease. J.Clin.Invest. 122 1377 PMID: 22406537

Hong et al (2016) Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-beta Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem.Res. 41 1192 PMID: 26738988

If you know of a relevant reference for FPS ZM1, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 RAGE Antagonists

关键词: FPS ZM1, FPS ZM1 supplier, FPSZM1, Inhibitors, Inhibits, Antagonist, RAGE, Receptor, for, advanced, glycation, end, products, RAP, antagonist, peptide, blood-brain, barrier, BBB, permeable, penetrant, AB42, Aβ, Aβ42, Alzheimer's, Disease, NF-kB/IkB, 6237, Tocris Bioscience

3 篇 FPS ZM1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 FPS ZM1 的部分引用包括：

Hui et al (2021) Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma. Exp Ther Med 21 470 PMID: 33767765

Venkat et al (2021) S100B Inhibition Attenuates Intestinal Damage and Diarrhea Severity During Clostridioides difficile Infection by Modulating Inflammatory Response. Front Cell Infect Microbiol 11 739874 PMID: 34568098

Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887

您是否知道使用了 Tocris FPS ZM1 的优秀论文？ 请告知我们.

FPS ZM1 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used FPS ZM1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Good inhibitor.
By Anonymous on 06/06/2020
分析类型： In Vivo
种属： Mouse
细胞系/组织： phagocyte

DMSO dilution 10 μM

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Multiple Sclerosis Poster

Multiple Sclerosis Poster

Multiple sclerosis (MS) is an autoimmune disease that is characterized by focal demyelination and axon degeneration in the central nervous system. This poster summarizes the neurobiology and current therapies of MS.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.