FTY 720

Cat. No. 6176 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent S1P receptor agonist; also immunosuppressant

别名： Fingolimod,Gilenya

化学名： 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride

纯度： ≥99% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for FTY 720

FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P₁,₃,₄ and ₅ receptors (EC₅₀ values are 0.3 - 0.6 nM for S1P₁, ₄ and ₅ and ~3 nM for S1P₃). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

化合物库 for FTY 720

FTY 720 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for FTY 720

分子量	343.93
公式	C₁₉H₃₃NO₂.HCl
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	162359-56-0
PubChem ID	107969
InChI Key	SWZTYAVBMYWFGS-UHFFFAOYSA-N
Smiles	CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FTY 720

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	34.39	100
	DMSO	34.39	100

制备储备液 for FTY 720

以下数据基于产品分子量 343.93。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.91 mL	14.54 mL	29.08 mL
5 mM	0.58 mL	2.91 mL	5.82 mL
10 mM	0.29 mL	1.45 mL	2.91 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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产品说明书 for FTY 720

分析证书/产品说明书

化学品安全技术说明书

参考文献 for FTY 720

参考文献是支持产品生物活性的出版物。

Hopkins et al (2011) ACS chemical neuroscience molecule spotlight on gil. (fingolimod; FTY720). ACS Chem. Neurosci. 2 116 PMID: 22778861

Brinkmann et al (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 9 883 PMID: 21031003

Coelho et al (2007) The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J.Pharmacol.Exp.Ther. 323 626 PMID: 17726159

Shiow et al (2006) CD69 acts downstream of IF.-alpha/beta to inhibit S1P₁ and lymphocyte egress from lymphoid organs. Nature 440 540 PMID: 16525420

If you know of a relevant reference for FTY 720, please let us know.

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